Published in
Royal Society of Chemistry, Chemical Communications, 2, p. 156-158, 2007
DOI: 10.1039/b611122j
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ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme
Journal article published in 2007 by
Angela Casini,
Guido Mastrobuoni,
Claudia Temperini,
Chiara Gabbiani 
,
Simona Francese,
Gloriano Moneti,
Claudiu T. Supuran,
Andrea Scozzafava,
Luigi Messori
,
Simona Francese,
Gloriano Moneti,
Claudiu T. Supuran,
Andrea Scozzafava,
Luigi Messori
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Abstract
The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug–protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.