Published in
Royal Society of Chemistry, Chemical Communications, 46(51), p. 9436-9439, 2015
DOI: 10.1039/c5cc01751c
Links
Tools
Cisplatin binding to human serum albumin: A structural study
This paper is available in a repository.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.