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Royal Society of Chemistry, MedChemComm, 4(3), p. 494

DOI: 10.1039/c2md00269h

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Development of novel ionic liquids based on ampicillin

Journal article published in 2012 by Ricardo Ferraz, Manuel Nunes da Ponte ORCID, Luis C. Branco ORCID, Isabel M. Marrucho, Joao M. M. Araujo ORCID, Cristina Prudencio, Luis Paulo N. Rebelo ORCID, Manuel Nunes Ponte, Joao Paulo Noronha ORCID, Zeljko Petrovski
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This paper is available in a repository.

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Abstract

Novel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of a moderately basic ammonia solution of ampicillin with different organic cation hydroxides. The relevant physical and thermal properties of these novel ionic liquids based on ampicillin were also evaluated.