Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 30(10), p. 5916
DOI: 10.1039/c2ob07135e
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α-N-Linked glycopeptides: Conformational analysis and bioactivity as lectin ligands
,
Francisco Javier Cañada,
Sabine André,
Cinzia Colombo,
Fabio Doro,
Hans-Joachim Gabius ,
Anna Bernardi,
Jesús Jiménez-Barbero
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Abstract
Natural N-glycosylation involves a β-anomeric linkage connecting the sugar to one asparagine residue of the protein. We herein report NMR- and modelling-based data on glycomimetics containing α-glycosidic linkages. The bioactivity of α-Gal-containing glycopeptides has been documented by revealing binding to two plant lectins, i.e. a potent β-trefoil toxin (Viscum album agglutinin) and β-sandwich lectin (Erythrina corallodendron agglutinin), by NMR protocols. Docking provided insights into the 3D structures of the resulting complexes. These results provide the basis to introduce α-substituted neoglycopeptides to the toolbox of scaffold for the design of potent lectin inhibitors.