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Royal Society of Chemistry, Organic and Biomolecular Chemistry, 5(13), p. 1317-1321, 2015
DOI: 10.1039/c4ob02317j
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Stereoselective synthesis of fluorinated aminoglycosyl phosphonates
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Abstract
We describe the conjugate addition of lithiated difluoro-methanephosphonates to a diverse range of nitroglycals as a convenient method for the highly stereoselective synthesis of fluorinated aminoglycosyl phosphonates. Our approach provides opportunities to produce hydrolytically stable mimics of biologically important aminoglycosyl phosphates.