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Royal Society of Chemistry, Chemical Communications, 5(47), p. 1545-1547

DOI: 10.1039/c0cc04371k

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A new method for the construction of the hydroxylated tropane skeleton: enantioselective synthesis of (-)-Bao Gong Teng A

Journal article published in 2011 by Geng-Jie Lin, 黄培强, Xiao Zheng, Pei-Qiang Huang ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

An efficient and highly diastereoselective method for the construction of the hydroxylated tropane skeleton is described. The method features a new intramolecular reductive coupling reaction of N-acyl N,O-acetal with aldehyde, cooperatively mediated by BF(3)center dot OEt(2) and SmI(2). On the basis of this method, a new enantioselective total synthesis of (-)-Bao Gong Teng A has been accomplished. ; NSF of China[20832005, 21072160]; National Basic Research Program (973 Program) of China[2010CB833200]