Royal Society of Chemistry, Chemical Communications, 5(47), p. 1545-1547
DOI: 10.1039/c0cc04371k
Full text: Unavailable
An efficient and highly diastereoselective method for the construction of the hydroxylated tropane skeleton is described. The method features a new intramolecular reductive coupling reaction of N-acyl N,O-acetal with aldehyde, cooperatively mediated by BF(3)center dot OEt(2) and SmI(2). On the basis of this method, a new enantioselective total synthesis of (-)-Bao Gong Teng A has been accomplished. ; NSF of China[20832005, 21072160]; National Basic Research Program (973 Program) of China[2010CB833200]