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Royal Society of Chemistry, Chemical Communications, 77(51), p. 14447-14450

DOI: 10.1039/c5cc02428e

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Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

Journal article published in 2015 by Michael T. Cook, Sarah L. Smith, Vitaliy V. Khutoryanskiy ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo stomach mucosa, when using a dynamic method of assessing mucoadhesion.