Royal Society of Chemistry, Dalton Transactions, 10, p. 1952-1960, 2003
DOI: 10.1039/b211885h
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A series of new, relatively hydrophilic, N,N-dialkyl-N′-(2,2-dimethylpropyl)thioureas (HLn) (n = 1, N,N-dimethyl-; n = 2, N-pyrrolidyl-; n = 3, N-piperidyl-) and their corresponding cis-[M(Ln-S,O)2] [for M = Pt(II), Pd(II); n = 1–3] and fac-[Rh(Ln-S,O)3] (n = 2, 3) complexes have been prepared and characterised. The crystal and molecular structures of fac-tris(N-pyrrolidyl-N′-(2,2-dimethylpropyl)thioureato)rhodium(III) and cis-bis(N-piperidyl-N′-(2,2-dimethylpropyl)thioureato)platinum(II) are reported, as representative examples. The favourable physiochemical properties and ready formation of stable mono-isomeric cis-[Pt(Ln-S,O)2] and cis-[Pd(Ln-S,O)2] complexes with these ligands makes these compounds suitable for the reversed-phase high performance liquid chromatography (RP-HPLC) determination of traces of these metal ions in hydrochloric acid, following in situ complex formation in a homogeneous acetonitrile–hydrochloric acid phase and subsequent salt (NaCl) induced phase separation. A study of the effect of ligand structure on the separation behaviour of cis-[M(Ln-S,O)2] of Pd(II) and Pt(II) complexes has been undertaken, showing that the nature of the ligand has a significant influence on the separation characteristics of these complexes.