Published in
Royal Society of Chemistry, Dalton Transactions, 28(42), p. 10112
DOI: 10.1039/c3dt51152a
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A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)
Journal article published in 2013 by
Sara Piccinonna,
Nicola Margiotta 
,
Nunzio Denora,
Rosa Maria Iacobazzi ,
Iacobazzi Rm,
Concetta Pacifico,
Giuseppe Trapani,
Giovanni Natile
,
Nunzio Denora,
Rosa Maria Iacobazzi ,
Iacobazzi Rm,
Concetta Pacifico,
Giuseppe Trapani,
Giovanni Natile
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Abstract
A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new (99m)Tc or (188/186)Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.