Published in
Royal Society of Chemistry, Chemical Communications, 21(51), p. 4390-4393, 2015
DOI: 10.1039/c5cc00285k
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A multiple gadolinium complex decorated fullerene as a highly sensitive T1 contrast agent
Journal article published in 2015 by
Lirong Wang,
Xianglong Zhu,
Xingyan Tang,
Changqiang Wu,
Zijian Zhou,
Chengjie Sun,
Shun-Liu Deng,
Hua Ai,
Jinhao Gao 
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Abstract
We report a simple strategy to construct a multiple gadolinium complex decorated fullerene (CGDn) as an enhanced T1 contrast agent. The CGDn exhibits much higher T1 relaxivity (∼49.7 mM(-1) s(-1)) than individual Gd-DOTA, and shows excellent T1 contrast enhancement ability both in vitro and in vivo.