Royal Society of Chemistry, Chemical Communications, 22(51), p. 4576-4578, 2015
DOI: 10.1039/c4cc09598g
Full text: Unavailable
The first enantioselective total synthesis of (+)-methoxystemofoline (2) and (+)-isomethoxystemofoline (3) is reported. The synthesis employed the halide-assisted bromotropanonation method that we developed recently to construct the core structure, and Overman’s strategy for the implementation of the butenolide moiety. Through this work, the structure of methoxystemofoline was revised as 2 with an E-alkene, and its absolute configuration was established.