Royal Society of Chemistry, Chemical Communications, 70(51), p. 13470-13473
DOI: 10.1039/c5cc05469a
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Chemical formation of dehydroalanine has been widely used for the post-translational modification of protein and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used to cleanly carry out this transformation.