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Royal Society of Chemistry, Chemical Communications, 70(51), p. 13470-13473

DOI: 10.1039/c5cc05469a

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Chemical generation and modification of peptides containing multiple dehydroalanines

Journal article published in 2015 by Philip M. Morrison, Patrick J. Foley, Stuart L. Warriner ORCID, Michael E. Webb ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Chemical formation of dehydroalanine has been widely used for the post-translational modification of protein and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used to cleanly carry out this transformation.