Published in
Royal Society of Chemistry, Chemical Communications, 31(51), p. 6777-6780
DOI: 10.1039/c5cc01412c
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Rh/Cu-catalyzed multiple C–H, C–C, and C–N bond cleavage: facile synthesis of pyrido[2,1-a]indoles from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols
Journal article published in 2015 by
Ting Li,
Zhen Wang 
,
Mingliang Zhang,
Hui-Jun Zhang ,
Ting-Bin Wen
,
Mingliang Zhang,
Hui-Jun Zhang ,
Ting-Bin Wen
This paper is made freely available by the publisher.
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Abstract
An unusual Rh/Cu-catalyzed synthesis of pyrido[2,1-a]indoles starting from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols was presented. The multi-step cascade transformations formally involve the cleavage of two C-H, three C-C, and one C-N bonds with concomitant construction of two C-H, four C-C, and one C-N bonds with excellent chemoselectivity in one-pot reaction.