Published in
Royal Society of Chemistry, Chemical Communications, 86(49), p. 10100, 2013
DOI: 10.1039/c3cc46400h
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The mode of action of anticancer gold-based drugs: A structural perspective
Journal article published in 2013 by
Luigi Messori 
,
Federica Scaletti,
Lara Massai,
Maria A. Cinellu,
Chiara Gabbiani ,
Alessandro Vergara,
Antonello Merlino
,
Federica Scaletti,
Lara Massai,
Maria A. Cinellu,
Chiara Gabbiani ,
Alessandro Vergara,
Antonello Merlino
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Abstract
The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.