This study examined whether resting EEG asymmetries are related to symptom severity and treatment outcome in spider phobia. Prior to treatment, EEG was recorded in a sample of spider phobic patients (N = 16). Correlations between frontal and parietal asymmetries in alpha power, on the one hand, and pre- and post-treatment symptom measures, on the other hand, were then computed. Only relative right parietal hyperactivation was found to be related to higher pre-treatment spider phobia scores. No convincing correlations between EEG asymmetry and post-treatment outcome measures were found. The findings suggest that cognitive processes mediated by the right hemisphere may modulate pre-treatment phobic symptoms.