Published in

Royal Society of Chemistry, Soft Matter, 9(5), p. 1771

DOI: 10.1039/b820228a

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Active soft glassy rheology of adherent cells

Journal article published in 2009 by Philip Kollmannsberger, Ben Fabry ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Adherent cells show a wide range of complex mechanical behavior that traditionally has been accounted for by different mechanisms and models, each of which can explain a limited subset of cell behavior. Experimental evidence suggests that nearly all aspects of mechanical cell behavior are closely associated with the cell's contractile machinery of actin and myosin filaments. We propose that the molecular details of actin-myosin interactions can be combined in a unified active soft glassy model that considers the arrangement of stress fibers at the macro-scale, and the soft-glassy non-equilibrium interaction of myosin and actin filaments at the micro-scale.