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Wiley-VCH Verlag, ChemInform, 21(42), p. no-no, 2011

DOI: 10.1002/chin.201121144

Royal Society of Chemistry, Chemical Communications, 3(47), p. 1054-1056

DOI: 10.1039/c0cc03478a

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Preparation of benzolactams by Pd(ii)-catalyzed carbonylation of N-unprotected arylethylamines

Journal article published in 2011 by Blanca López, Aleix Rodriguez, David Santos, Joan Albert, Xavier Ariza, Jordi Garcia, Jaume Granell ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

An unprecedented NH(2)-directed Pd(II)-catalytic carbonylation of quaternary aromatic α-amino esters to yield 6-membered benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for the success of the process.