Wiley-VCH Verlag, ChemInform, 21(42), p. no-no, 2011
Royal Society of Chemistry, Chemical Communications, 3(47), p. 1054-1056
DOI: 10.1039/c0cc03478a
Full text: Unavailable
An unprecedented NH(2)-directed Pd(II)-catalytic carbonylation of quaternary aromatic α-amino esters to yield 6-membered benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for the success of the process.