Published in
Royal Society of Chemistry, Chemical Communications, 6(52), p. 1234-1237
DOI: 10.1039/c5cc07619f
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High-Affinity Sequence-Selective DNA binding by Iridium(III) polypyridyl organometallopeptides
Journal article published in 2015 by
Ilaria Gamba 
,
Iria Salvado,
Rosa F. Brissos,
Patrick Gamez,
Jose Brea,
Maria Isabel Loza ,
M. Eugenio Vázquez,
M. Eugenio Vazquez,
Miguel Vázquez López
,
Iria Salvado,
Rosa F. Brissos,
Patrick Gamez,
Jose Brea,
Maria Isabel Loza ,
M. Eugenio Vázquez,
M. Eugenio Vazquez,
Miguel Vázquez López
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Abstract
We demonstrate the application of solid-phase peptide synthesis methods for assembling polynuclear Ir(III) organo-metallopeptides that exhibit high DNA-binding affinity, sequence selectivity, and high cytotoxic effect towards a set of cancer cell lines.