Published in
Royal Society of Chemistry, Chemical Communications, 11(50), p. 1341-1343, 2014
DOI: 10.1039/c3cc48587k
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Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy
Journal article published in 2013 by
Hiroyuki Yamakoshi 
,
Almar F. Palonpon,
Kosuke Dodo,
Jun Ando,
Satoshi Kawata,
Katsumasa Fujita,
Mikiko Sodeoka
,
Almar F. Palonpon,
Kosuke Dodo,
Jun Ando,
Satoshi Kawata,
Katsumasa Fujita,
Mikiko Sodeoka
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Abstract
We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by Raman microscopy. Nitriles, structure-sensitive Raman tags, are used to detect the two distinct molecular structures, demonstrating the potential of Raman microscopy for structure-based imaging of bioactive small molecules.