Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 5(10), p. 941-944, 2012
DOI: 10.1039/c1ob06699d
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Stereoselective synthesis of N-aryl proline amides by biotransformation-Ugi-Smiles sequence
Journal article published in 2011 by
Anass Znabet,
Sara Blanken,
Elwin Janssen,
Frans J. J. de Kanter,
Madeleine Helliwell,
Nicholas J. Turner,
Eelco Ruijter 
,
Romano V. A. Orru
,
Romano V. A. Orru
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Abstract
An efficient combination of MAO-N-catalyzed desymmetrization of cyclic meso-amines with Ugi-Smiles multicomponent chemistry produced optically pure N-aryl proline amides. This method represents the first report of a fully asymmetric Ugi-Smiles process.