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Royal Society of Chemistry, Dalton Transactions, 47(44), p. 20523-20531

DOI: 10.1039/c5dt03037d

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Organometallic rhodium(III) and iridium(III) cyclopentadienyl complexes with curcumin and bisdemethoxycurcumin co-ligands

Journal article published in 2015 by Riccardo Pettinari, Fabio Marchetti, Claudio Pettinari ORCID, Francesca Condello, Agnese Petrini, Rosario Scopelliti, Tina Riedel, Paul J. Dyson
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A series of half-sandwich cyclopentadienyl rhodium(iii) and iridium(iii) complexes of the type [Cp*M(curc/bdcurc)Cl] and [Cp*M(curc/bdcurc)(PTA)][SO3CF3], in which Cp* = pentamethylcyclopentadienyl, curcH = curcumin and bdcurcH = bisdemethoxycurcumin as O^O-chelating ligands, and PTA = 1,3,5-triaza-7-phosphaadamantane, is described. The X-ray crystal structures of three of the complexes, i.e. [Cp*Rh(curc)(PTA)][SO3CF3] (), [Cp*Rh(bdcurc)(PTA)][SO3CF3] () and [Cp*Ir(bdcurc)(PTA)][SO3CF3] (), confirm the expected "piano-stool" geometry. With the exception of , the complexes are stable under pseudo-physiological conditions and are moderately cytotoxic to human ovarian carcinoma (A2780 and A2780cisR) cells and also to non-tumorigenic human embryonic kidney (HEK293) cells, but lack the cancer cell selectivity observed for related arene ruthenium(ii) complexes.