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Royal Society of Chemistry, Chemical Communications, 10(48), p. 1478-1480, 2012

DOI: 10.1039/c1cc16725a

Wiley-VCH Verlag, ChemInform, 25(43), p. no-no, 2012

DOI: 10.1002/chin.201225028

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ChemInform Abstract: Copper(I) Catalyzed Asymmetric 1,2-Addition of Grignard Reagents to α-Methyl Substituted α,β-Unsaturated Ketones.

Journal article published in 2011 by Ashoka V. R. Madduri, Adriaan J. Minnaard ORCID, Syuzanna R. Harutyunyan
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The first catalytic enantioselective 1,2-addition of Grignard reagents to ketones is presented. This additive-free copper(I) catalyzed 1,2-addition provides chiral allylic tertiary alcohols with an er of up to 98:2 and excellent yields due to the complete shift of overwhelming 1,4-selectivity of copper(I)-catalysts towards 1,2-selectivity in the addition reaction to enones.