Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 1(8), p. 137-141
DOI: 10.1039/b916601g
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Dendron-anchored organocatalysts: The asymmetric reduction of imines with trichlorosilane, catalysed by an amino acid-derived formamide appended to a dendron
Journal article published in 2010 by
Marek Figlus,
Stuart T. Caldwell,
Dawid Walas,
Gulen Yesilbag,
Graeme Cooke 
,
Pavel Kocovský,
Andrei V. Malkov,
Amitav Sanyal
,
Pavel Kocovský,
Andrei V. Malkov,
Amitav Sanyal
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Abstract
Asymmetric reduction of ketimines with trichlorosilane can be catalysed by the Lewis-basic N-methylvaline-derived formamide anchored to a soluble dendron () with good enantioselectivity (</=94% ee) and low catalyst loading (typically 5 mol%) at room temperature in toluene. This protocol represents an improvement and simplification of the isolation procedure and recovery of the catalyst.