Royal Society of Chemistry, Organic and Biomolecular Chemistry, 1(8), p. 137-141
DOI: 10.1039/b916601g
Full text: Unavailable
Asymmetric reduction of ketimines with trichlorosilane can be catalysed by the Lewis-basic N-methylvaline-derived formamide anchored to a soluble dendron () with good enantioselectivity (</=94% ee) and low catalyst loading (typically 5 mol%) at room temperature in toluene. This protocol represents an improvement and simplification of the isolation procedure and recovery of the catalyst.