Published in
Royal Society of Chemistry, Chemical Communications, 28(51), p. 6161-6163, 2015
DOI: 10.1039/c5cc00356c
Links
Tools
Development of an Acid Ceramidase Activity-Based Probe
Journal article published in 2015 by
Cécile M. J. Ouairy,
Maria J. Ferraz,
Rolf G. Boot,
Marc P. Baggelaar,
Mario van der Stelt,
Monique Appelman,
Gijsbert A. van der Marel,
Johannes M. F. G. Aerts,
Herman S. Overkleeft 
,
Bobby I. Florea ,
J. M. Aerts,
Hans Aerts
,
Bobby I. Florea ,
J. M. Aerts,
Hans Aerts
This paper is available in a repository.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe.