Published in
Royal Society of Chemistry, Molecular BioSystems, 3(10), p. 380, 2014
DOI: 10.1039/c3mb70447e
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Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation
Journal article published in 2014 by
Andrew Millard,
David J. Scanlan 
,
Connor Gallagher,
Andrew Marsh ,
Paul C. Taylor
,
Connor Gallagher,
Andrew Marsh ,
Paul C. Taylor
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Abstract
Biosynthesis of retinoic acid from retinaldehyde (retinal) is catalysed by an aldehyde dehydrogenase (ALDH) and its oxidation by cytochrome P450 enzymes (CYPs). Herein we show by phylogenetic analysis that the ALDHs and CYPs in the retinoic acid pathway in animals are much closer in evolutionary terms to cyanobacterial orthologs than would be expected from the standard models of evolution.