Published in
Royal Society of Chemistry, Molecular BioSystems, 6(4), p. 532, 2008
DOI: 10.1039/b719782a
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Acid cleavable PEG-lipids for applications in a ternary gene delivery vector
Journal article published in 2008 by
John B. Wong,
Stephanie Grosse,
Alethea B. Tabor,
Stephen L. Hart 
,
Helen C. Hailes
,
Helen C. Hailes
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Abstract
A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.