Responsive polymers have been widely studied as actuators in response to external stimuli and exhibit promising applications in a wide variety of fields. However, the actuating direction of most polymers cannot be precisely controlled, and the generated low stress and poor stability cannot meet practical applications either. Here conjugated polymer/aligned multi-walled carbon nanotube (MWCNT) composites are designed to undergo anisotropic and reversible bending/unbending actuations driven by solvents. The actuating direction was accurately controlled to be perpendicular to the MWCNT length, which is realized through the orientation of conjugated polymers induced by aligned MWCNTs. The actuation generates a stress of 15 MPa, appropriately 42 times of the strongest human muscle, and the reversible actuations are repeated for 300 cycles without fatigue. These composite artificial muscles can be widely used in many fields such as sensors and actuators.