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Royal Society of Chemistry, Chemical Communications, 95(50), p. 15067-15070

DOI: 10.1039/c4cc05085a

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Synthesis aided structural determination of amyloid-β(1–15) glycopeptides, new biomarkers for Alzheimer's disease

Journal article published in 2014 by Peng Wang, Jonas Nilsson, Gunnar Brinkmalm ORCID, Göran Larson, Xuefei Huang ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Unique tyrosine glycosylated amyloid-β(1-15) glycopeptides were synthesized with well-defined stereochemistry at the glycosidic linkages. Aided by these glycopeptides and tandem mass spectrometry analysis, the naturally existing amyloid-β glycopeptides, isolated from Alzheimer's disease patients, were determined to contain an α-linked N-acetyl galactosamine at the modified tyrosine 10 residue. Glycosylation can significantly impact the properties of amyloid-β as the glycopeptide has much lower affinity for Cu(+) ions.