Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 12(8), p. 2771
DOI: 10.1039/c002418j
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Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
Journal article published in 2010 by
Anthony Bugaut,
Raphaël Rodriguez,
Sunita Kumari,
Shang-Te Danny Hsu 
,
Shankar Balasubramanian
,
Shankar Balasubramanian
This paper is available in a repository.
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Abstract
Herein, we show that a naturally occurring RNA G-quadruplex element within the 5' UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5' UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.