α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes - James L. Galman, David Steadman, Sarah Bacon, Phattaraporn Morris, Mark E. B. Smith, John M. Ward, Paul A. Dalby, Helen C. Hailes - Dissemin

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Wiley-VCH Verlag, ChemInform, 6(42), p. no-no, 2011

DOI: 10.1002/chin.201106028

Royal Society of Chemistry, Chemical Communications, 40(46), p. 7608

DOI: 10.1039/c0cc02911d

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α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

Journal article published in 2010 by James L. Galman, David Steadman

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, Sarah Bacon, Phattaraporn Morris, Mark E. B. Smith, John M. Ward, Paul A. Dalby, Helen C. Hailes

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Abstract

Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.