Royal Society of Chemistry, Chemical Communications, 80(49), p. 9104
DOI: 10.1039/c3cc45875j
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A cysteine-selective tagging method in water is reported, based on rapid displacement of a pyridyl nitro-substituent in simple pyridines and lanthanide complexes. The conjugation reaction creates a short link between the tag and peptide, holding the peptide closer to the Ln(3+) ion and with reduced flexibility compared to existing methods.