Published in
Royal Society of Chemistry, CrystEngComm, 2(14), p. 362-365
DOI: 10.1039/c1ce05799e
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A cocrystal is the key intermediates for the production of a new polymorph of Vorinostat
Journal article published in 2011 by
Cristina Puigjaner,
Rafael Barbas,
Anna Portell,
Ismael Valverde,
Xavier Vila,
Xavier Alcobé,
Mercè Font-Bardia,
Rafel Prohens 
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Abstract
A new kinetically stable polymorph of Vorinostat has been discovered as a result of a polymorph screening, however an impurity is always formed in its preparation by crystallization. The interaction of Vorinostat with ammonia yields a new cocrystal which transforms easily through thermal desorption into the new polymorph with a high degree of purity.