In this paper, we have reported a new, visible-light-driven photocatalyst composed of 2D mesoporous TiO2 on reduced graphene oxide, which enables enhanced absorption of visible light, has outstanding charge separation ability, and a large surface area. The graphene–2D mesoporous TiO2 (GOMTi) was prepared via a simple hydrothermal process by ternary self-assembly of metal oxide precursors, graphene oxide, and surfactant. The structural strength and large interfacial contact between the graphene and two dimensional TiO2 sheet lead to high performance photocatalyst, as compared to a conventional graphene-TiO2 nanostructure composite. In the test for degradation of methylene blue, the photodegradation rate of GOMTi was ~9 times the rate of common TiO2 nanoparticles (p25), due to the enhanced synergetic effects of graphene and TiO2.