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Cambridge University Press, Psychological Medicine, 10(39), p. 1587

DOI: 10.1017/s0033291709005273

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Modelling complex pathways between late-life depression and disability: evidence for mediating and moderating factors

Journal article published in 2009 by Isabelle Carrière, Dominique Villebrun, Karine Pérès, Robert Stewart ORCID, Karen Ritchie, Marie-Laure Ancelin ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Previous research has consistently shown an association between depression and disability in the elderly but little is known about the mechanisms linking the two. Recent longitudinal population studies have shown considerable inconsistency in the criteria used to establish causality and terms such as mediation and effect modification have been frequently applied incorrectly in terms of the inferences drawn. We underline the necessity to adopt more stringent theoretical criteria for the establishment of intermediary effects in the relationship between depression and disability to better identify cross-validated potential intervention points for reducing the risk of disablement and depression.