Published in
Royal Society of Chemistry, Dalton Transactions, 21(41), p. 6399, 2012
DOI: 10.1039/c2dt12479c
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Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages.
Journal article published in 2012 by
Anne-Sophie Bernard,
H. Y. Vincent Ching,
Claire Giroud,
H. Y. Vincent Ching,
Anne Meunier,
Vinita Ambike,
Christian Amatore 
,
Manon Guille Collignon,
Manon Guille Collignon,
Frédéric Lemaître,
Clotilde Policar
,
Manon Guille Collignon,
Manon Guille Collignon,
Frédéric Lemaître,
Clotilde Policar
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Abstract
SOD-mimics are small complexes that reproduce the activity of superoxide dismutases, natural proteins that catalytically dismutate the superoxide anion. Activated macrophages, which produce ROS and RNS fluxes, constitute a relevant model to challenge antioxidant activity in a cellular context and were used to test a Mn-complex which was shown to efficiently alter the flow of O(2)(-), ONOO(-) and H(2)O(2).