Published in
Royal Society of Chemistry, Chemical Communications, 42(51), p. 8845-8848
DOI: 10.1039/c5cc01986a
Links
Tools
Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction
Journal article published in 2015 by
Bin Wang,
Jinwei Ren,
Liyuan Li,
Fang Fan,
Fang Guo,
Guohui Pan,
Guomin Ai,
Bertrand Aigle 
,
Keqiang Fan,
Keqian Fan,
Keqian Yang
,
Keqiang Fan,
Keqian Fan,
Keqian Yang
This paper is available in a repository.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
The biosynthesis of diazobenzofluorene kinamycins requires a hitherto uncharacterized B-ring contraction. Via detailed genetic and enzymatic analyses we unambiguously characterized the conserved pairs of oxidases, AlpJ and AlpK homologs, as nature's machinery for benzofluorenone formation, which paves the way for the investigation of the following diazo assembly.