Published in
Royal Society of Chemistry, Chemical Communications, 18(50), p. 2252-2254, 2014
DOI: 10.1039/c3cc46903d
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High mitochondrial accumulation of new gadolinium(III) agents within tumour cells
Journal article published in 2013 by
Daniel E. Morrison,
Jade B. Aitken,
Martin D. de Jonge,
Joseph A. Ioppolo,
Hugh H. Harris 
,
Louis M. Rendina
,
Louis M. Rendina
This paper is available in a repository.
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Abstract
The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10(10) Gd atoms per tumour cell.