Published in
Royal Society of Chemistry, Chemical Communications, 76(48), p. 9516, 2012
DOI: 10.1039/c2cc34399a
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New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: Effect of the base sequence on anti-HIV activity
Journal article published in 2012 by
Valentina D'Atri,
Giorgia Oliviero,
Jussara Amato,
Nicola Borbone,
Stefano D'Errico,
Luciano Mayol 
,
Vincenzo Piccialli,
Shozeb Haider ,
Bart Hoorelbeke,
Jan Balzarini,
Gennaro Piccialli
,
Vincenzo Piccialli,
Shozeb Haider ,
Bart Hoorelbeke,
Jan Balzarini,
Gennaro Piccialli
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Abstract
This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.