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Royal Society of Chemistry, Chemical Communications, 55(51), p. 11026-11029

DOI: 10.1039/c5cc02590g

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Bio-inspired Maillard-Like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal

Journal article published in 2015 by Shih-Ting Wang ORCID, Yiyang Lin ORCID, Christopher D. Spicer ORCID, Molly M. Stevens
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A simple and selective assay for detecting methylglyoxal (MGO), a metabolite associated with diabetes, was developed by combining a bio-inspired chemical reaction with the anti-aggregation of gold nanoparticles. This assay could detect MGO at as low as 1 μM by the naked eye and 0.05 μM by UV/vis spectrometry, within the clinical range marking oxidative stress in diabetes, and demonstrated high selectivity over other physiologically relevant ketones and aldehydes.