Published in
Royal Society of Chemistry, MedChemComm, 1(4), p. 175-179
DOI: 10.1039/c2md20196h
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Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing
Journal article published in 2013 by
Hadas Ganin,
Josep Rayo 
,
Neri Amara,
Niva Levy,
Pnina Krief,
P. Pnina Krief,
Michael M. Meijler
,
Neri Amara,
Niva Levy,
Pnina Krief,
P. Pnina Krief,
Michael M. Meijler
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Abstract
Sulforaphane and erucin, two natural isothiocyanates that are highly abundant in broccoli and other cruciferous vegetables, were found to strongly inhibit quorum sensing and virulence in Pseudomonas aeruginosa. Mechanistic evaluations of these effects suggest that these isothiocyanates are antagonists of the transcriptional activator LasR.