A new force field for the simulation of the adsorption of cycloalkanes in nanoporous silica affords a significant improvement over any previously employed force field. The simulated isotherms reproduce the most salient features in the experimental isotherms extremely well. The study of cyclo-pentane, -hexane, and -heptane adsorption in MFI-type silica indicates an inflection for cyclopentane but not for cyclohexane at intermediate pressure. If corroborated by experiments, such an inflection point would afford an excellent calibration point for further force field developments. At low pressures, mixture isotherms of cyclohexane and n-hexane show a temperature dependence on the selectivity in accordance with recent results by J. P. Fox and S. P. Bates, J. Phys. Chem., 2004, 108, 17136. This dependence is caused by a difference in temperature dependence of the Henry coefficient for both molecules. At high pressures entropy effects due to packing always favor the sorption of n-hexane. Furthermore, the influence of the flexibility of the zeolite framework on the adsorption of these rather bulky molecules is investigated. It is found that this influence of the flexibility on the adsorption of cyclohexane is as small as with n-alkanes.