Published in
Royal Society of Chemistry, Chemical Communications, 18(51), p. 3850-3853
DOI: 10.1039/c4cc10074c
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Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold
Journal article published in 2015 by
Maria Strocchia,
Stefania Terracciano,
Maria G. Chini,
Antonio Vassallo 
,
Maria C. Vaccaro,
Fabrizio Dal Piaz,
Fabrizio Dal Piaz,
Antonietta Leone,
Raffaele Riccio,
Ines Bruno,
Giuseppe Bifulco
,
Maria C. Vaccaro,
Fabrizio Dal Piaz,
Fabrizio Dal Piaz,
Antonietta Leone,
Raffaele Riccio,
Ines Bruno,
Giuseppe Bifulco
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Abstract
Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well-known natural and nature-inspired inhibitors of this second druggable Hsp90 site.