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Royal Society of Chemistry, Chemical Communications, 26(51), p. 5586-5589
DOI: 10.1039/c4cc09070e
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A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents
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Abstract
Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.