Published in
Royal Society of Chemistry, Chemical Communications, 4(51), p. 792-795, 2015
DOI: 10.1039/c4cc08915d
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A Nile blue based infrared fluorescent probe: Imaging tumors that over-express cyclooxygenase-2
Journal article published in 2014 by
Benhua Wang,
Jiangli Fan,
Xianwu Wang,
Hao Zhu,
Jingyun Wang,
Huiying Mu 
,
Xiaojun Peng
,
Xiaojun Peng
This paper is available in a repository.
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Abstract
The free Niblue-C6-IMC exists in a folded conformation where fluorescence is quenched, and when it binds to COX-2 in the Golgi apparatus of cancer cells, it is forced to adopt the unfolded state, and then fluorescence is turned on. Niblue-C6-IMC was proved to specifically target COX-2 by native polyacrylamide gel electrophoresis analysis.