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Royal Society of Chemistry, Soft Matter, 18(7), p. 8363

DOI: 10.1039/c1sm05481c

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Block Liposome and Nanotube Formation is a General Phenomenon of Two-Component Membranes Containing Multivalent Lipids

Journal article published in 2011 by Alexandra Zidovska, Kai K. Ewert ORCID, Joel Quispe, Bridget Carragher ORCID, Clinton S. Potter, Cyrus R. Safinya
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We report a study on the formation of block liposomes (BLs) and nanotubes from membranes comprised of mixtures of membrane curvature-stabilizing multivalent cationic lipids MVL3(3+) and MVL5(5+) with neutral 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC). In conjunction with prior work on MVLBG2(16+), our experiments suggest that BL and nanotube formation is a general phenomenon in membranes containing multivalent lipids, thus enhancing the relevance of BLs for applications such as gene/drug storage and delivery or templating.