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Royal Society of Chemistry, MedChemComm, 2(1), p. 149

DOI: 10.1039/c0md00026d

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Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Journal article published in 2010 by Meral Görmen, Pascal Pigeon ORCID, Siden Top, Anne Vessières, Marie-Aude Plamont, Elizabeth A. Hillard ORCID, Gérard Jaouen
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A series of new 1-[di-(4-R-phenyl)-methylidenyl)]-[3]ferrocenophanes, where R = OH, NH2, NHAc, and the phenyl substitution is mixed or identical, are highly antiproliferative against MDA-MB-231 and PC-3 cancer cells, with IC50 values ranging from 0 05-5 6 mu M on MDA-M B-231 and 0 02-12 5 mu M on PC-3