Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 17(12), p. 2778-2783, 2014
DOI: 10.1039/c4ob00202d
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Synthesis of a multibranched porphyrin-oligonucleotide scaffold for the construction of DNA-based nano-architectures.
,
Grégory Chatelain,
Arianna Filoramo,
Didier Gasparutto,
Christine Saint-Pierre,
Eric Le Cam,
Eric Le Cam ,
Olivier Piétrement,
Vincent Guérineau,
Stéphane Campidelli
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Abstract
: The interest in the functionalization of oligonucleotides with organic molecules has grown considerably over the last decade. In this work, we report on the synthesis and characterization of porphyrin-oligonucleotide hybrids containing one to four DNA strands (P1-P4). The hybrid P4, which inserts one porphyrin and four DNA fragments, was combined with gold nanoparticles and imaged by transmission electron microscopy.