Royal Society of Chemistry, Chemical Communications, 15(51), p. 3147-3150
DOI: 10.1039/c4cc08917k
Full text: Download
The interplay of Phe-Gly-Gly (FGG)-tagged proteins and bivalent FGG-tagged penta(ethylene glycol) as guest molecules with cucurbit[8]uril (Q8) hosts is studied to modulate the supramolecular assembly process. Ring structure formation of the bivalent guest molecule with Q8 leads to enhanced binding properties and efficient inhibition of protein assemblies.