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Royal Society of Chemistry, Chemical Communications, 15(51), p. 3147-3150

DOI: 10.1039/c4cc08917k

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Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulation

Journal article published in 2015 by Mellany Ramaekers, Spw Sjors Wijnands, Sjors P. W. Wijnands, Joost L. J. van Dongen, Jlj Joost van Dongen, Luc Brunsveld ORCID, Pyw Patricia Dankers, Patricia Y. W. Dankers
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This paper is available in a repository.

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Abstract

The interplay of Phe-Gly-Gly (FGG)-tagged proteins and bivalent FGG-tagged penta(ethylene glycol) as guest molecules with cucurbit[8]uril (Q8) hosts is studied to modulate the supramolecular assembly process. Ring structure formation of the bivalent guest molecule with Q8 leads to enhanced binding properties and efficient inhibition of protein assemblies.