Published in
Royal Society of Chemistry, Analyst, 5(139), p. 992-995, 2014
DOI: 10.1039/c3an02178e
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A mesofluidic platform integrating on-chip probe ultrasonication for multiple sample pretreatment involving denaturation, reduction, and digestion in protein identification assays by mass spectrometry
Journal article published in 2014 by
J. D. Nunes-Miranda,
Cristina Núñez,
Hugo M. Santos 
,
G. Vale,
Miguel Reboiro-Jato ,
Florentino Fdez-Riverola,
Carlos Lodeiro ,
Manuel Miró ,
J. L. Capelo
,
G. Vale,
Miguel Reboiro-Jato ,
Florentino Fdez-Riverola,
Carlos Lodeiro ,
Manuel Miró ,
J. L. Capelo
This paper is available in a repository.
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Abstract
The integration of ultrasound (US)-assisted sample processing on-chip in a lab-on-a-valve (LOV) format for automated high-throughput shotgun proteomic assays is herein presented for the first time. The proof of concept of this system was demonstrated with the analysis of three proteins and sera from patients with lymphoma or myeloma.